hotspot sequence island_index group coordinates cds_id cds_type name category 1671-0 MGV-GENOME-0231172 0 MGV-GENOME-0274583_CDS_0044 20654:21217:1 MGV-GENOME-0231172_CDS_0021 variable hypothetical protein 1671-0 MGV-GENOME-0239546 0 MGV-GENOME-0323981_CDS_0022 21508:21690:1 MGV-GENOME-0239546_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0239546 1 MGV-GENOME-0321868_CDS_0025 21769:22173:1 MGV-GENOME-0239546_CDS_0024 variable hypothetical protein 1671-0 MGV-GENOME-0262944 0 MGV-GENOME-0323981_CDS_0022 21510:21692:1 MGV-GENOME-0262944_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0262944 1 uvig_298282_CDS_0028 21771:23012:1 MGV-GENOME-0262944_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-0262944 2 IMGVR_UViG_3300045988_164015|3300045988|Ga0495776_186565_CDS_0091 23163:23912:1 MGV-GENOME-0262944_CDS_0025 variable hypothetical protein 1671-0 MGV-GENOME-0286570 0 MGV-GENOME-0323981_CDS_0022 21513:21695:1 MGV-GENOME-0286570_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0286570 1 uvig_298282_CDS_0028 21774:23015:1 MGV-GENOME-0286570_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-0286570 2 MGV-GENOME-0274583_CDS_0044 23005:23667:1 MGV-GENOME-0286570_CDS_0025 variable hypothetical protein 1671-0 MGV-GENOME-0249144 0 MGV-GENOME-0335086_CDS_0068 22413:22967:1 MGV-GENOME-0249144_CDS_0027 variable virion structural protein 1671-0 MGV-GENOME-0249144 1 IMGVR_UViG_3300045988_164015|3300045988|Ga0495776_186565_CDS_0091 22972:23721:1 MGV-GENOME-0249144_CDS_0028 variable hypothetical protein 1671-0 MGV-GENOME-0245226 0 MGV-GENOME-0302657_CDS_0045 20763:20921:1 MGV-GENOME-0245226_CDS_0021 intermediate hypothetical protein 1671-0 MGV-GENOME-0245226 1 MGV-GENOME-0318357_CDS_0035 20914:21141:1 MGV-GENOME-0245226_CDS_0022 intermediate hypothetical protein 1671-0 MGV-GENOME-0245226 2 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 21138:21311:1 MGV-GENOME-0245226_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0245226 3 MGV-GENOME-0289351_CDS_0048 21308:22258:1 MGV-GENOME-0245226_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-0245226 4 IMGVR_UViG_3300045988_070861|3300045988|Ga0495776_163791_CDS_0095 22255:22419:1 MGV-GENOME-0245226_CDS_0025 variable hypothetical protein 1671-0 MGV-GENOME-0260072 0 MGV-GENOME-0323981_CDS_0022 21513:21695:1 MGV-GENOME-0260072_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0260072 1 uvig_298282_CDS_0028 21774:23015:1 MGV-GENOME-0260072_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-0260072 2 SAMEA2737833_a1_ct115630_vs1_CDS_0067 23234:24325:1 MGV-GENOME-0260072_CDS_0025 intermediate hypothetical protein 1671-0 MGV-GENOME-0260072 3 MGV-GENOME-0333558_CDS_0064 24319:24786:1 MGV-GENOME-0260072_CDS_0026 intermediate hypothetical protein 1671-0 MGV-GENOME-0260072 4 MGV-GENOME-0302657_CDS_0045 24794:24952:1 MGV-GENOME-0260072_CDS_0027 intermediate hypothetical protein 1671-0 MGV-GENOME-0260072 5 MGV-GENOME-0318357_CDS_0035 24945:25172:1 MGV-GENOME-0260072_CDS_0028 intermediate hypothetical protein 1671-0 MGV-GENOME-0260072 6 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 25172:25345:1 MGV-GENOME-0260072_CDS_0029 intermediate hypothetical protein 1671-0 MGV-GENOME-0260072 7 MGV-GENOME-0289351_CDS_0048 25342:26298:1 MGV-GENOME-0260072_CDS_0030 intermediate hypothetical protein 1671-0 MGV-GENOME-0260072 8 IMGVR_UViG_3300001525_000598|3300001525|chfec4_10000083_CDS_0052 26299:26511:1 MGV-GENOME-0260072_CDS_0031 intermediate hypothetical protein 1671-0 MGV-GENOME-0260072 9 uvig_126404_CDS_0009 26522:26752:1 MGV-GENOME-0260072_CDS_0032 variable hypothetical protein 1671-0 MGV-GENOME-0257305 0 SAMEA2737833_a1_ct115630_vs1_CDS_0067 20694:21779:1 MGV-GENOME-0257305_CDS_0021 intermediate hypothetical protein 1671-0 MGV-GENOME-0257305 1 MGV-GENOME-0333558_CDS_0064 21773:22240:1 MGV-GENOME-0257305_CDS_0022 intermediate hypothetical protein 1671-0 MGV-GENOME-0257305 2 MGV-GENOME-0302657_CDS_0045 22248:22406:1 MGV-GENOME-0257305_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0257305 3 MGV-GENOME-0318357_CDS_0035 22399:22626:1 MGV-GENOME-0257305_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-0257305 4 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 22626:22799:1 MGV-GENOME-0257305_CDS_0025 intermediate hypothetical protein 1671-0 MGV-GENOME-0257305 5 MGV-GENOME-0306136_CDS_0049 22796:23347:1 MGV-GENOME-0257305_CDS_0026 variable hypothetical protein 1671-0 MGV-GENOME-0261088 0 MGV-GENOME-0323981_CDS_0022 21506:21688:1 MGV-GENOME-0261088_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0261088 1 uvig_298282_CDS_0028 21767:23008:1 MGV-GENOME-0261088_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-0261088 2 MGV-GENOME-0261088_CDS_0025 23167:23499:1 MGV-GENOME-0261088_CDS_0025 variable hypothetical protein 1671-0 MGV-GENOME-0261088 3 MGV-GENOME-0333558_CDS_0064 23493:23960:1 MGV-GENOME-0261088_CDS_0026 intermediate hypothetical protein 1671-0 MGV-GENOME-0261088 4 MGV-GENOME-0302657_CDS_0045 23968:24126:1 MGV-GENOME-0261088_CDS_0027 intermediate hypothetical protein 1671-0 MGV-GENOME-0261088 5 MGV-GENOME-0318357_CDS_0035 24119:24346:1 MGV-GENOME-0261088_CDS_0028 intermediate hypothetical protein 1671-0 MGV-GENOME-0261088 6 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 24346:24519:1 MGV-GENOME-0261088_CDS_0029 intermediate hypothetical protein 1671-0 MGV-GENOME-0261088 7 Han_2018_ERR1398257_NODE_3241_length_5767_cov_3.160714_CDS_0010 24516:24881:1 MGV-GENOME-0261088_CDS_0030 variable hypothetical protein 1671-0 MGV-GENOME-0302127 0 MGV-GENOME-0323981_CDS_0022 21508:21690:1 MGV-GENOME-0302127_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0302127 1 uvig_298282_CDS_0028 21769:23010:1 MGV-GENOME-0302127_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-0302127 2 MGV-GENOME-0333558_CDS_0064 23225:23692:1 MGV-GENOME-0302127_CDS_0025 intermediate hypothetical protein 1671-0 MGV-GENOME-0302127 3 MGV-GENOME-0302657_CDS_0045 23700:23855:1 MGV-GENOME-0302127_CDS_0026 intermediate hypothetical protein 1671-0 MGV-GENOME-0302127 4 MGV-GENOME-0318357_CDS_0035 23852:24109:1 MGV-GENOME-0302127_CDS_0027 intermediate hypothetical protein 1671-0 MGV-GENOME-0302127 5 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 24091:24267:1 MGV-GENOME-0302127_CDS_0028 intermediate hypothetical protein 1671-0 MGV-GENOME-0302127 6 MGV-GENOME-0245738_CDS_0046 24264:24395:1 MGV-GENOME-0302127_CDS_0029 variable hypothetical protein 1671-0 MGV-GENOME-0302127 7 MGV-GENOME-0289351_CDS_0048 24379:25335:1 MGV-GENOME-0302127_CDS_0030 intermediate hypothetical protein 1671-0 MGV-GENOME-0302127 8 IMGVR_UViG_3300001525_000598|3300001525|chfec4_10000083_CDS_0052 25336:25548:1 MGV-GENOME-0302127_CDS_0031 intermediate hypothetical protein 1671-0 MGV-GENOME-0267912 0 MGV-GENOME-0323981_CDS_0022 21516:21698:1 MGV-GENOME-0267912_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0267912 1 uvig_298282_CDS_0028 21777:23018:1 MGV-GENOME-0267912_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-0267912 2 SAMEA2737833_a1_ct115630_vs1_CDS_0067 23241:24452:1 MGV-GENOME-0267912_CDS_0025 intermediate hypothetical protein 1671-0 MGV-GENOME-0267912 3 MGV-GENOME-0333558_CDS_0064 24446:24913:1 MGV-GENOME-0267912_CDS_0026 intermediate hypothetical protein 1671-0 MGV-GENOME-0267912 4 MGV-GENOME-0302657_CDS_0045 24921:25076:1 MGV-GENOME-0267912_CDS_0027 intermediate hypothetical protein 1671-0 MGV-GENOME-0267912 5 MGV-GENOME-0318357_CDS_0035 25073:25330:1 MGV-GENOME-0267912_CDS_0028 intermediate hypothetical protein 1671-0 MGV-GENOME-0267912 6 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 25312:25491:1 MGV-GENOME-0267912_CDS_0029 intermediate hypothetical protein 1671-0 MGV-GENOME-0267912 7 MGV-GENOME-0245738_CDS_0046 25484:25615:1 MGV-GENOME-0267912_CDS_0030 variable hypothetical protein 1671-0 MGV-GENOME-0267912 8 MGV-GENOME-0289351_CDS_0048 25599:26555:1 MGV-GENOME-0267912_CDS_0031 intermediate hypothetical protein 1671-0 MGV-GENOME-0267912 9 IMGVR_UViG_3300001525_000598|3300001525|chfec4_10000083_CDS_0052 26556:26768:1 MGV-GENOME-0267912_CDS_0032 intermediate hypothetical protein 1671-0 MGV-GENOME-0279560 0 MGV-GENOME-0323981_CDS_0022 21508:21690:1 MGV-GENOME-0279560_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0279560 1 uvig_298282_CDS_0028 21769:23010:1 MGV-GENOME-0279560_CDS_0024 intermediate integrase 1671-0 MGV-GENOME-0279560 2 Ma_2019_SRR413700_NODE_169_length_77513_cov_4.888753_CDS_0011 22976:24058:-1 MGV-GENOME-0279560_CDS_0025 variable transposase 1671-0 MGV-GENOME-0279560 3 MGV-GENOME-0333558_CDS_0064 24351:24818:1 MGV-GENOME-0279560_CDS_0026 intermediate hypothetical protein 1671-0 MGV-GENOME-0279560 4 MGV-GENOME-0302657_CDS_0045 24826:24981:1 MGV-GENOME-0279560_CDS_0027 intermediate hypothetical protein 1671-0 MGV-GENOME-0279560 5 MGV-GENOME-0318357_CDS_0035 24978:25235:1 MGV-GENOME-0279560_CDS_0028 intermediate hypothetical protein 1671-0 MGV-GENOME-0279560 6 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 25217:25393:1 MGV-GENOME-0279560_CDS_0029 intermediate hypothetical protein 1671-0 MGV-GENOME-0279560 7 MGV-GENOME-0245738_CDS_0046 25390:25521:1 MGV-GENOME-0279560_CDS_0030 variable hypothetical protein 1671-0 MGV-GENOME-0279560 8 MGV-GENOME-0289351_CDS_0048 25505:26461:1 MGV-GENOME-0279560_CDS_0031 intermediate hypothetical protein 1671-0 MGV-GENOME-0279560 9 IMGVR_UViG_3300001525_000598|3300001525|chfec4_10000083_CDS_0052 26462:26674:1 MGV-GENOME-0279560_CDS_0032 intermediate hypothetical protein 1671-0 MGV-GENOME-4415537 0 MGV-GENOME-0323981_CDS_0022 21507:21689:1 MGV-GENOME-4415537_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-4415537 1 uvig_298282_CDS_0028 21768:23009:1 MGV-GENOME-4415537_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-4415537 2 MGV-GENOME-0333558_CDS_0064 23265:23732:1 MGV-GENOME-4415537_CDS_0025 intermediate hypothetical protein 1671-0 MGV-GENOME-4415537 3 MGV-GENOME-0302657_CDS_0045 23740:23898:1 MGV-GENOME-4415537_CDS_0026 intermediate hypothetical protein 1671-0 MGV-GENOME-4415537 4 MGV-GENOME-0318357_CDS_0035 23891:24118:1 MGV-GENOME-4415537_CDS_0027 intermediate hypothetical protein 1671-0 MGV-GENOME-4415537 5 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 24118:24291:1 MGV-GENOME-4415537_CDS_0028 intermediate hypothetical protein 1671-0 MGV-GENOME-4415537 6 MGV-GENOME-0289351_CDS_0048 24288:25244:1 MGV-GENOME-4415537_CDS_0029 intermediate hypothetical protein 1671-0 MGV-GENOME-4415537 7 IMGVR_UViG_3300001525_000598|3300001525|chfec4_10000083_CDS_0052 25245:25457:1 MGV-GENOME-4415537_CDS_0030 intermediate hypothetical protein 1671-0 MGV-GENOME-4415537 8 uvig_126404_CDS_0009 25468:25698:1 MGV-GENOME-4415537_CDS_0031 variable hypothetical protein 1671-0 MGV-GENOME-0278086 0 MGV-GENOME-0323981_CDS_0022 21507:21689:1 MGV-GENOME-0278086_CDS_0023 intermediate hypothetical protein 1671-0 MGV-GENOME-0278086 1 uvig_298282_CDS_0028 21768:23009:1 MGV-GENOME-0278086_CDS_0024 intermediate hypothetical protein 1671-0 MGV-GENOME-0278086 2 MGV-GENOME-0333558_CDS_0064 23075:23542:1 MGV-GENOME-0278086_CDS_0025 intermediate hypothetical protein 1671-0 MGV-GENOME-0278086 3 MGV-GENOME-0302657_CDS_0045 23550:23708:1 MGV-GENOME-0278086_CDS_0026 intermediate hypothetical protein 1671-0 MGV-GENOME-0278086 4 MGV-GENOME-0318357_CDS_0035 23701:23928:1 MGV-GENOME-0278086_CDS_0027 intermediate hypothetical protein 1671-0 MGV-GENOME-0278086 5 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 23925:24098:1 MGV-GENOME-0278086_CDS_0028 intermediate hypothetical protein 1671-0 MGV-GENOME-0278086 6 MGV-GENOME-0289351_CDS_0048 24095:25045:1 MGV-GENOME-0278086_CDS_0029 intermediate hypothetical protein 1671-0 MGV-GENOME-0278086 7 IMGVR_UViG_3300045988_070861|3300045988|Ga0495776_163791_CDS_0095 25042:25206:1 MGV-GENOME-0278086_CDS_0030 variable hypothetical protein 1671-0 MGV-GENOME-0321372 0 MGV-GENOME-0323981_CDS_0022 23269:23451:1 MGV-GENOME-0321372_CDS_0026 intermediate hypothetical protein 1671-0 MGV-GENOME-0321372 1 uvig_298282_CDS_0028 23530:24771:1 MGV-GENOME-0321372_CDS_0027 intermediate hypothetical protein 1671-0 MGV-GENOME-0321372 2 SAMEA2737833_a1_ct115630_vs1_CDS_0067 24787:25878:1 MGV-GENOME-0321372_CDS_0028 intermediate hypothetical protein 1671-0 MGV-GENOME-0321372 3 MGV-GENOME-0333558_CDS_0064 25872:26339:1 MGV-GENOME-0321372_CDS_0029 intermediate hypothetical protein 1671-0 MGV-GENOME-0321372 4 MGV-GENOME-0302657_CDS_0045 26347:26505:1 MGV-GENOME-0321372_CDS_0030 intermediate hypothetical protein 1671-0 MGV-GENOME-0321372 5 MGV-GENOME-0318357_CDS_0035 26498:26725:1 MGV-GENOME-0321372_CDS_0031 intermediate hypothetical protein 1671-0 MGV-GENOME-0321372 6 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 26722:26895:1 MGV-GENOME-0321372_CDS_0032 intermediate hypothetical protein 1671-0 MGV-GENOME-0321372 7 MGV-GENOME-0289351_CDS_0048 26892:27842:1 MGV-GENOME-0321372_CDS_0033 intermediate hypothetical protein 1671-0 MGV-GENOME-0321372 8 IMGVR_UViG_3300045988_070861|3300045988|Ga0495776_163791_CDS_0095 27839:28003:1 MGV-GENOME-0321372_CDS_0034 variable hypothetical protein 1671-0 uvig_500704 0 MGV-GENOME-0323981_CDS_0022 21147:21329:1 uvig_500704_CDS_0023 intermediate hypothetical protein 1671-0 uvig_500704 1 uvig_298282_CDS_0028 21408:22649:1 uvig_500704_CDS_0024 intermediate integrase 1671-0 uvig_500704 2 uvig_301934_CDS_0024 22800:23414:1 uvig_500704_CDS_0025 variable hypothetical protein 1671-0 uvig_500704 3 uvig_185605_CDS_0004 23416:24177:1 uvig_500704_CDS_0026 variable hypothetical protein 1671-0 uvig_500704 4 uvig_72480_CDS_0022 24194:24871:1 uvig_500704_CDS_0027 variable hypothetical protein 1671-0 uvig_500704 5 uvig_56619_CDS_0002 25088:26728:-1 uvig_500704_CDS_0028 variable ABCF_OptrA-NCBIFAM ABC-F type ribosomal protection protein OptrA (NF000514.1) AMR (AMRFinderPlus) 1671-0 uvig_500704 6 uvig_222340_CDS_0051 27013:29991:1 uvig_500704_CDS_0029 variable hypothetical protein 1671-0 uvig_500704 7 SAMEA2737833_a1_ct115630_vs1_CDS_0067 30065:31114:1 uvig_500704_CDS_0030 intermediate DNA helicase 1671-0 uvig_500704 8 MGV-GENOME-0333558_CDS_0064 31108:31575:1 uvig_500704_CDS_0031 intermediate anti-repressor 1671-0 uvig_500704 9 MGV-GENOME-0302657_CDS_0045 31583:31741:1 uvig_500704_CDS_0032 intermediate hypothetical protein 1671-0 uvig_500704 10 MGV-GENOME-0318357_CDS_0035 31734:31961:1 uvig_500704_CDS_0033 intermediate hypothetical protein 1671-0 uvig_500704 11 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 31961:32134:1 uvig_500704_CDS_0034 intermediate hypothetical protein 1671-0 uvig_500704 12 MGV-GENOME-0306136_CDS_0049 32131:32703:1 uvig_500704_CDS_0035 variable hypothetical protein 1671-0 uvig_449978 0 MGV-GENOME-0323981_CDS_0022 21513:21695:1 uvig_449978_CDS_0023 intermediate hypothetical protein 1671-0 uvig_449978 1 uvig_298282_CDS_0028 21774:23015:1 uvig_449978_CDS_0024 intermediate integrase 1671-0 uvig_449978 2 uvig_301934_CDS_0024 23166:23771:1 uvig_449978_CDS_0025 variable hypothetical protein 1671-0 uvig_449978 3 uvig_185605_CDS_0004 23787:24551:1 uvig_449978_CDS_0026 variable hypothetical protein 1671-0 uvig_449978 4 uvig_230716_CDS_0084 24570:25244:1 uvig_449978_CDS_0027 variable hypothetical protein 1671-0 uvig_449978 5 Ma_2019_SRR341691_NODE_17_length_218703_cov_6.052729_CDS_0295 25357:25476:-1 uvig_449978_CDS_0028 variable hypothetical protein 1671-0 uvig_449978 6 uvig_123160_CDS_0074 25665:29885:-1 uvig_449978_CDS_0029 variable hypothetical protein 1671-0 uvig_449978 7 Ma_2019_SRR341691_NODE_17_length_218703_cov_6.052729_CDS_0297 30149:31165:1 uvig_449978_CDS_0030 variable hypothetical protein 1671-0 uvig_449978 8 uvig_78007_CDS_0001 31450:35112:1 uvig_449978_CDS_0031 variable DNA polymerase 1671-0 uvig_449978 9 uvig_34559_CDS_0059 35134:35625:1 uvig_449978_CDS_0032 variable single strand annealing protein 1671-0 uvig_449978 10 uvig_593844_CDS_0064 35685:36548:1 uvig_449978_CDS_0033 variable hypothetical protein 1671-0 uvig_449978 11 MGV-GENOME-0350722_CDS_0057 36572:36868:1 uvig_449978_CDS_0034 variable hypothetical protein 1671-0 uvig_449978 12 SAMEA2737833_a1_ct115630_vs1_CDS_0067 36869:38080:1 uvig_449978_CDS_0035 intermediate DNA helicase 1671-0 uvig_449978 13 MGV-GENOME-0333558_CDS_0064 38074:38541:1 uvig_449978_CDS_0036 intermediate anti-repressor 1671-0 uvig_449978 14 MGV-GENOME-0302657_CDS_0045 38549:38707:1 uvig_449978_CDS_0037 intermediate hypothetical protein 1671-0 uvig_449978 15 IMGVR_UViG_3300029214_000247|3300029214|Ga0168682_100233|350-61685_CDS_0068 38704:38877:1 uvig_449978_CDS_0038 intermediate hypothetical protein 1671-0 uvig_449978 16 MGV-GENOME-0289351_CDS_0048 38874:39830:1 uvig_449978_CDS_0039 intermediate hypothetical protein 1671-0 uvig_449978 17 IMGVR_UViG_3300001525_000598|3300001525|chfec4_10000083_CDS_0052 39831:40043:1 uvig_449978_CDS_0040 intermediate hypothetical protein 1671-0 uvig_449978 18 uvig_126404_CDS_0009 40054:40284:1 uvig_449978_CDS_0041 variable hypothetical protein